Table 2.

ADH and ALDH2 allele frequencies

			ADH1B*2	ADH1B*3	ADH1C*1	ALDH2*2
			rs1229984	rs2066702	rs1693482**	rs671
		Position	4:99,318,162	4:100,229,017	4:99,304,835	12:111,803,962
		Genome Allele	T	A	C	A
		RNA Allele	A	T	G	A
		Amino acid	His48	Cys370	Arg272	Lys504
Group	Code	Population
AFR	ACB	African Carribbeans in Barbados	0.010	0.193	0.891	0.005
AFR	ASW	Americans of African Ancestry in SW USA		0.205	0.861
AFR	ESN	Esan in Nigera		0.273	0.929
AFR	GWD	Gambian in Western Divisons in The Gambia		0.142	0.912	0.004
AFR	LWK	Luhya in Webuye, Kenya		0.141	0.859
AFR	MSK	Mende in Sierra Leone		0.088	0.906
AFR	YRI	Yoruba in Ibadan, Nigera		0.282	0.926
AMR	CLM	Colombians from Medellin, Colombia	0.074		0.755
AMR	MXL	Mexican Ancestry from Los Angeles USA	0.086		0.719	0.008
AMR	PEL	Peruvians from Lima, Peru	0.012		0.824	0.006
AMR	PUR	Puerto Ricans from Puerto Rico	0.063		0.635
ASN	CDX	Chinese Dai in Xishuangbanna, China	0.634		0.887	0.043
ASN	CHB	Han Chinese in Bejing, China	0.709		0.951	0.160
ASN	CHS	Southern Han Chinese	0.757		0.929	0.271
ASN	JPT	Japanese in Tokyo, Japan	0.731		0.928	0.240
ASN	KHV	Kinh in Ho Chi Minh City, Vietnam	0.646		0.919	0.136
EUR	CEU	Utah Residents (CEPH) with Northern and Western European ancestry	0.015		0.525
EUR	FIN	Finnish in Finland			0.490
EUR	GBR	British in England and Scotland	0.005		0.560
EUR	IBS	Iberian population in Spain	0.065		0.692
EUR	TSI	Toscani in Italia	0.051		0.692
SAN	BEB	Bengali from Bangladesh	0.017		0.820
SAN	GIH	Gujarati Indian from Houston, Texas	0.024		0.718
SAN	ITU	Indian Telugu from the UK	0.015		0.765
SAN	PJL	Punjabi from Lahore, Pakistan	0.042		0.672
SAN	STU	Sri Lankan Tamil from the UK	0.005		0.662

Allele corresponding to the variant noted is shown on the genomic reference strand and in the RNA (note that the ADH transcripts run in the opposite direction). Positions are on the GRCh38/hg38 human genome assembly. Data are from the 1000 genomes project, Phase 3 (The 1000 Genomes Project Consortium et al., 2015). Blanks are <0.001. Groups: AFR = African, AMR=American, ASN=East Asian, EUR=European, SAN=South Asian. Code: 3 letter identifier for population.

^**Frequencies are identical to the more frequently studied SNP rs698 (genome C, RNA G, Val350), except that for rs698, YRI=0.931, ITU= 0.760. For data on a wider range of populations and SNPs, see the alfred database https://alfred.med.yale.edu (Rajeevan et al., 2012).