Skip to main content
. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Alcohol Clin Exp Res. 2018 Nov 11;42(12):2281–2297. doi: 10.1111/acer.13904

Table 3.

ALDH genes and enzyme kinetics

Approve
d Gene
Symbola 		Approved Gene
Namea 		Synonyms RNA:
RefSeq
Accession
ID		 Subunit
encoded		 KM,
acetaldehyde
(mM)		 Activity
Kcat
(min-1)		 RefSeq
position
ALDH2 aldehyde dehydrogenase 2 ALDHI; ALDH-E2; ALDM NM_000690 - - 12:111766887-111809985
ALDH2*1 ALDH2*Glu504 ALDH2*1 ALDH2[Glu504]b 0.2 280
ALDH2*2 ALDH2*Lys504 ALDH2*2 ALDH2[Lys504]b c
ALDH1B1 aldehyde dehydrogenase 1 family member B1 ALDH5; ALDHX NM_000692 55 655 9:38392664-38398665
ALDH1A1 aldehyde dehydrogenase 1 family member A1 ALDH1; ALDH-E1; ALDH11; RALDH1; ALDC NM_000689 180 380 9:72900662-72953317

RefSeq positions are from the Human GRCh38/hg38 genome assembly. Data on kinetics are from (Klyosov, 1996) (ALDH2, ALDH1A2) and (Stagos et al., 2010) (ALDH1B1).

a

HUGO Gene Nomenclature Committee.

b

Position in precursor protein; aa487 in the mature protein.

c

ALDH2 is essentially inactive under physiological conditions.