Table 3.
Sensitivity and specificity of CL Detect and Loopamp in 274 patients with suspected CL attending the NMLCP clinic in Kabul, Afghanistan. Reference for the analysis: combined skin-scraping microscopy and dental broach PCR.
| Index tests | Cases, n = 257 |
Non-cases, n = 17 |
Diagnostic performance |
|||
|---|---|---|---|---|---|---|
| Positive | Negative | Positive | Negative | Sensitivity [95% CI] | Specificity [95% CI] | |
| Tests in Kabul | ||||||
| CL Detect | 168 | 89 | 0 | 17 | 65·4% [59·2–71·2] | 100% [80·5–100] |
| Loopamp | 225 | 32 | 5 | 12 | 87·6% [82·9–91·3] | 70·6% [44·0–89·7] |
| Test at AMC | ||||||
| Loopamp-AMC | 237 | 20 | 1 | 16 | 92·2% [88·2–95·2] | 94·1% [71·3–99·8] |
CL Detect: CL Detect™ Rapid Diagnostic Test; Loopamp: Loopamp™ Leishmania Detection Kit, CI: Confidence Interval.