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. 2018 Dec 7;1:220. doi: 10.1038/s42003-018-0230-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Kinetic model based on observations tested and supported by SPR. a Kinetic framework was developed from all observations from time-lapse fluorescence microscopy (aggregates, lipid particle evolution), lipid extraction experiments (nanoscale losses), and FRAP (molecular-scale binding) and translated into b a testable hypothesis of oligomer-membrane disruption. c SPR sensorgram of a high (10 μM) and low (1 μM) concentration. The Meta and Para showed similarities at high concentration, especially within the dissociation phase (PBS wash). At low concentrations, the oligomers were significantly different in both the association and dissociation phases. All runs did not return to the original baseline, with some irreversible changes. d Model fit of 5 μM Meta. e Model fit of 5 μM Para. f Concentration dependence of differential aggregate formation (OL*), where the Para showed higher activity at lower concentration, below the MIC of the Meta