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. 2018 Dec 7;8:17712. doi: 10.1038/s41598-018-36277-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Role of Xrp1 in cell competition-driven elimination of loser cells. Xrp1 localized in the nucleulus sitting on rDNA. In a competitive scenario, Xrp1 acts as a transcription factor in loser cells, driving the expression of Xrp1 itself, of pro-apoptotic target genes (hid, rpr), of genes involved in innate immunity (Dif), in compensatory proliferation (Upd3) and in protein degradation-dependent apoptosis and cell proliferation arrest (Nedd4). Xrp1, because of its double involvement in the elimination of loser cells and in DNA repair, putatively acts as a genomic caretaker in a p53-independent fashion.