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. 2018 Jun 21;32(12):2701–2705. doi: 10.1038/s41375-018-0164-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Distribution of normal residual B-cells and their major subsets in peripheral blood of MBL and CLL cases vs. non-MBL controls. a The absolute number of residual normal B-cells. b The absolute number of pre-germinal center B-cells; white boxes represent immature B-cells (left Y-axis scale), while gray boxes represent naïve B-cells (right Y-axis scale). c The absolute number of antigen-experienced B-cells; white boxes represent plasma cells (left Y-axis scale), while gray boxes represent memory B-cells (right Y-axis scale). In all panels, notched boxes represent 25th and 75th percentile values; the lines in the middle correspond to median values and vertical lines represent the highest and lowest values that are neither outliers nor extreme values. *P ≤ 0.05 vs. controls; **P ≤ 0.01 vs. controls; ***P ≤ 0.001 vs. controls. MBL^lo low-count monoclonal B-cell lymphocytosis, MBL^hi high-count monoclonal B-cell lymphocytosis, CLL chronic lymphocytic leukemia