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. 2018 Jun 21;32(12):2701–2705. doi: 10.1038/s41375-018-0164-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Distribution of PB antigen-experienced B-cell subsets expressing distinct Ig-subclasses and soluble Ig-subclass plasma titers grouped according to the position they occupy in the IGHC gene blocks. a, b The absolute number of IgM⁺ and switched plasma cells, respectively. c, d The absolute number of IgMD⁺ un-switched memory B-cells and switched memory B-cells are displayed, respectively. e, f Soluble IgM titers in plasma and the sum of the soluble levels of the different switched Ig-subclasses according to the distinct position that they occupy in the IGHC gene, respectively. b, c, and f White boxes represent the sum of those Ig-subclasses encoded in the second IGHC gene block, while gray boxes represent the sum of those Ig-subclasses encoded in the third IGHC gene block. The relative position and order of the different gene segments of the IGHC gene that encode for the different Ig-subclasses are depicted on the top of the figure. Notched boxes represent 25th and 75th percentile values; the lines in the middle correspond to median values and vertical lines represent the highest and lowest values that are neither outliers nor extreme values; *P ≤ 0.05 vs. controls; **P ≤ 0.01 vs. controls; ***P ≤ 0.001 vs. controls. MBL^lo low-count monoclonal B-cell lymphocytosis, MBL^hi high-count monoclonal B-cell lymphocytosis, CLL chronic lymphocytic leukemia