Fig. 2.

KDM3A promotes TAC-induced hypertrophic remodeling. WT and Kdm3a-Tg (Tg) mice were subjected to Sham (S) and TAC (T) surgery. Echocardiograph was performed on mice and hearts were harvested after 6 weeks for histological and biochemical analysis. a H&E staining of histologic sections of WT and Kdm3a-Tg mouse hearts. Scale bar, 1 mm. b HW/BW, c relative myocyte cell size, d LW/BW, and e relative fibrotic area of WT and Kdm3a-Tg mouse hearts. f Left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), percent of fractional shortening (FS%), and heart rate (HR, beat/min). g Relative mRNA of canonical fetal gene markers (Nppa, Nppb, and Myh7), Fhl1, and Col1a2. n = 6-10 ± SEM. ^{*, #}p < 0.05 (ANOVA). *WT TAC vs. WT Sham. ^#, Tg-TAC vs. WT-TAC