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. 2018 Dec 7;9:5230. doi: 10.1038/s41467-018-07173-2

Fig. 4.

Fig. 4

KDM3A promotes transcription of a pro-fibrotic gene program. a Volcano plot of differentially expressed genes in Kdm3a KO mouse hearts compared to those in WT mouse hearts at 6 weeks post-TAC surgeries. Timp1 is among the most downregulated genes in KO hearts. b Heatmaps of differentially expressed genes in KO vs WT and Kdm3a-Tg vs WT mouse hearts at 6 weeks post-TAC surgery, showing differentially expressed genes are inversely regulated in KO vs Tg hearts. c GO analysis of differentially downregulated genes in KO vs WT TAC mouse hearts. Relative mRNA of genes involved in fibrosis in Kdm3a-/- (d) and Kdm3a-Tg (e) mouse hearts 6 weeks post-Sham and TAC surgery. mRNA transcripts were measured by qRT-PCR, normalized against internal Gapdh, and expressed relative to Sham WT mice. n = 5 ± SEM. *, #p<0.05 (ANOVA). *, WT TAC vs. WT Sham. #, Tg-TAC vs. WT-TAC