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. 2018 Dec 7;9:5230. doi: 10.1038/s41467-018-07173-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — JIB-04 blocks TAC-induced hypertrophic remodeling and fibrosis. a Experimental protocol of JIB-04 and control vehicle (Veh) treatment of WT and Kdm3a-Tg mice. JIB-04/Veh were given to mice at either day 1 or 2 (exp 1) or 21 (exp 2) post-TAC. b %FS, c HW/BW ratio, d relative cell size, e percentage of fibrotic area, and f relative fold change of fetal genes and Timp1 of WT sham, WT TAC and Kdm3a-Tg TAC mouse heart at the end of experiment 1. n = 5-6 ± SEM, *, ^#, ^$, p < 0.05 (ANOVA). *, WT TAC vs WT Sham. ^#, JIB-04 WT TAC vs Veh WT-TAC. ^$, JIB-04 Tg TAC vs Veh TG TAC. g Western blot of TIMP1 in vehicle or JIB-04 treated WT mouse hearts at post-sham/TAC week 6 in experiment 1. h %FS over treatment period, i HW/BW, j relative cell size, and k % fibrotic area at end of experiment 2 of Sham and TAC Kdm3a-Tg mouse hearts treated with vehicle or JIB-04. n = 5 ± SEM, *p < 0.05 (ANOVA)