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. 2018 Dec 7;8:17717. doi: 10.1038/s41598-018-36139-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of 15-PGDH, COX-2, and miR-21 from TCGA gastric cancer data analysis. (a) TCGA gastric cancer data, miR-181, miR-769, and miR-21 showed high correlation with 15-PGDH (HPGD). (b) the miR-21 expression level was negatively correlated with 15-PGDH (HPGD) and positively correlated with COX-2 (PTGS2). (c) the levels of miR-21 and COX-2 (PTGS2) were higher in the tumor tissue than in normal tissue, but 15-PGDH (HPGD) mRNA expression was lower in the tumor tissue.