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. 2018 Dec 7;8:17717. doi: 10.1038/s41598-018-36139-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a,b) 15-PGDH expression change after miR-21 transfection to gastric cancer cell lines. Protein expression (a), as well as mRNA expression (b), was inhibited after transfection. (c,d) proliferation (c) and apoptosis (d) assay of gastric cancer cell lines after miR-21 transfection. Cells showed increased proliferation and decreased apoptosis when miR-21 was transfected. Data are mean values from three independent experiments, (b–d, *P < 0.05, **P < 0.001). (e) representative photomicrographs of miR-21 CISH from patient samples. In the tumor area (arrows), 15-PGDH was not expressed, whereas COX-2, PGE2, and miR-21 were high. (d) the relative expression of miR-21 was also higher in the patient tumor samples.