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. 2018 Dec 7;8:17734. doi: 10.1038/s41598-018-36045-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detectability indexes (d′) of simulated 4-mm-diameter solid non-calcified nodules as a function of the image reconstruction algorithm at regular (a) and reduced (b) dose levels. At regular dose, mean (95% confidence intervals) d’ ranged from 30.0 (29.9, 30.1) to 28.8 (28.8, 28.9) and 91.9 (91.6, 92.2) for FBP and 0% to 100% ASiR-V, respectively; whereas at reduced dose, mean (95% confidence intervals) d′ varied from 30.0 (29.9, 30.1) to 19.5 (19.5, 19.6) and 63.0 (62.9, 63.2) for FBP and 0% to 100% ASiR-V, respectively. Compared with FBP, detectability remained excellent (AUC ≥ 0.91), regardless of ASiR-V and dose levels. Detectability increased significantly with increasing ASiR-V levels to peak at 100% ASiR-V. Error bars represent 95% confidence intervals; they overlap with vertical bars. The solid and dashed lines represent 95% and 99% AUC, respectively.