Table 1.

Replication analyses of GWAS loci for bipolar disorder in an independent Han Chinese sample (1146 BPD cases and 1956 controls)

CHR	SNP	POS	Nearest Gene	Allele	OR	pValue	Ref.	Frequency		Two-tailed p value	One-tailed p value	OR	95% CIs
								Case	Control
2	rs17183814	166152389	SCN2A	G/A	1.142	2.02E−09	14	0.873	0.856	0.0623	0.0311	1.153	0.993-1.340
3	rs2302417	52814256	ITIH3	T/A	1.076	6.59E−11	14	0.609	0.590	0.144	0.0718	1.083	0.974-1.205
3	rs3804640	107793709	CD47	A/G	1.065	1.99E−08	14	0.865	0.848	0.0738	0.0369	1.147	0.987-1.334
4	rs11724116	162294038	FSTL5	C/T	1.088	2.37E−08	14	0.863	0.858	0.571	0.285	1.045	0.898-1.215
6	rs10455979	166995260	RPS6KA2	G/C	1.064	4.31E−08	14	0.703	0.715	0.336	0.168	0.944	0.840-1.061
7	rs4236274	1896413	MAD1L1	A/G	1.149	8.49E−12	15	0.478	0.445	0.0146	0.00731	1.140	1.026-1.266
7	rs4332037	1950809	MAD1L1	T/C	1.170	1.91E−09	17	0.115	0.097	0.0209	0.0104	1.218	1.030-1.441
9	rs12553324	23347865	ELAVL2	G/C	1.120	5.87E−09	15	0.498	0.512	0.297	0.148	0.946	0.853-1.050
10	rs10821745*	62136206*	ANK3	G/T	1.145	6.76E−09	14	0.238	0.236	0.835	0.418	1.013	0.896-1.145
10	rs78089757	127112829	intergenic	A/G	1.410	3.99E−07	17	0.026	0.019	0.0881	0.0440	1.358	0.955-1.931
11	rs174576	61603510	FADS1/2	A/C	1.130	1.34E−10	17	0.457	0.430	0.0459	0.0229	1.110	1.002-1.230
11	rs7122539	66662731	RCE1	G/A	1.067	3.77E−08	14	0.517	0.496	0.113	0.0565	1.086	0.980-1.204
11	rs12575685	70517927	SHANK2	A/G	1.073	7.71E−09	14	0.278	0.265	0.285	0.143	1.066	0.948-1.197
11	rs12290811	79083620	ODZ4	A/T	1.190	7.81E−11	18	0.062	0.057	0.428	0.214	1.093	0.878-1.360
11	rs329674	133776948	LOC646543	A/G	1.220	9.59E−08	17	0.193	0.198	0.678	0.339	0.973	0.855-1.107
12	rs10744560	2387099	CACNA1C	T/C	1.076	3.62E−10	14	0.060	0.053	0.287	0.143	1.130	0.902-1.415
15	rs4447398	42904904	HAUS2	A/C	1.099	9.37E−09	14	0.270	0.274	0.701	0.350	0.977	0.870-1.099
16	rs11647445	9926966	GRIN2A	G/T	1.079	1.08E−10	14	0.076	0.076	0.978	0.489	1.003	0.826-1.217
17	rs76317718	8222777	ARHGEF15	G/T	1.190	2.24E−07	17	0.723	0.725	0.848	0.424	0.989	0.882-1.109
17	rs112114764	42201041	HDAC5	G/T	1.071	2.45E−08	14	0.802	0.790	0.244	0.122	1.080	0.949-1.229
20	rs6130764	43750410	STK4	T/C	1.064	3.25E−08	14	0.859	0.855	0.732	0.366	1.027	0.883-1.194

Note:

^*rs10821745 is a proxy SNP for rs10994318 (r² = 0.945 in Chinese and r² = 1.000 in Europeans from 1000 Genomes Project), which has been reported in a previous GWAS¹⁴, and the rs10821745’s position is also shown in Table 1

The frequency and OR are based on the first allele shown in the fifth column

CHR chromosome, SNP single nucleotide polymorphism, POS position, OR odds ratio, Ref. reference, CIs confidence intervals

The significant p values (p < 0.05) were marked in bold