Table 4.
Association of rs78089757[A-allele] with bipolar disorder in East Asian populations
| Sample | Ancestry | Case | Control | Fre_Case | Fre_Control | Two-tailed p value | OR | 95% CIs |
|---|---|---|---|---|---|---|---|---|
| China | Chinese | 1146 | 1956 | 0.0255 | 0.0191 | 0.0881 | 1.358 | 0.955–1.931 |
| 1KGenome59 | Chinese | 208 | 0.00962 | |||||
| CONVERGE10 | Chinese | 5222 | 0.0160 | |||||
| China | Chinese | 1908 | 0.0183 | |||||
| Combined Chinese | 1146 | 9294 | 0.0255 | 0.0169 | 0.00352 | 1.526 | 1.149–2.028 | |
| Japan 0117 | Japanese | 1545 | 7408 | 0.041 | 0.032 | 0.00627 | 1.330 | 1.087–1.628 |
| Japan 0217 | Japanese | 1419 | 54,479 | 0.050 | 0.035 | 1.44E−05 | 1.470 | 1.235–1.750 |
| Meta-analysis | 4110 | 71,181 | / | / | 5.22E−09 | 1.429 | 1.268–1.610 |
Note: Test of heterogeneity: I2 = 0, p value = 0.673. OR odds ratio, CIs confidence intervals; 1KGenome, 1000 Genomes Project. The genotype data of rs78089757 in the 1000 Genomes Project includes 103 CHB (Han Chinese in Beijing, China) and 105 CHS (Southern Han Chinese, China) subjects. The additional Chinese control individuals (n = 1908) have not been published before