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. 2018 Dec 7;8:17700. doi: 10.1038/s41598-018-35884-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generation of mouse experimental model by NMDA excitotoxic amino acid. (A) Schematic illustration of intravitreal injection of NMDA; All injections were performed under ora serrata by glass needle. (B) For evaluation of mice model, analyses were performed on a distinct distance of optic nerve. (C,D) Histological analyses of GCC thickness 7 days post injection. Data significantly decreased in NMDA samples versus vehicle treated and normal mice. (E) Quantitative spider plot analysis depicting significant decrease in retinal thickness in NMDA samples. (F,G) Histological analysis of number of ganglion cells 7 days post injection. Data significantly decreased in NMDA samples versus vehicle treated and normal mice. GCC: ganglion cell complex; ONL: outer nuclear layer; INL: inner nuclear layer; GCL: ganglion cell layer; ONH: optic nerve head. (*P < 0.05 versus other groups, error bar: means ± SD).