Fig. 4.

The approach used to determine the exclusivity of each mode of gene regulation on expression for the TSG considered. a Depiction of the autocorrelation heatmap for the expression of the various negative regulators of the tumour suppressor gene, and the variables considered and their meaning, as depicted. b Plots depicting the spread of the percentiles on the empiric cumulative density function (CDF) for the distributions for the pairwise differences of the variables identified in a through a bootstrapping-based analysis, as described in the Methods section. Centre line of boxplots depicts median, bounded by interquartile range (IQR), and whiskers extending to 1.5 times the IQR