Table 2.

Betalactam provocation test

Symptoms	Procedures
Immediate reactions with negative skin tests	Graded challenge 1/10 TD (1/100 TD or 1/1000 TD when risk is high, e.g. severe asthma) then 2/10 TD and 7/10 TD every 30 min 2 h observation after last dose
Delayed reactions	Graded challenge as DPT for immediate reactions, or a full-dose challenge. The daily therapeutic dose is given at home for a minimum of 5 days up to 7 days.
Positive skin tests Anaphylaxis	Desensitization

TD therapeutic dose