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Methods of drug provocation test for NBLA
| Symptoms | Procedures |
|---|---|
| Mild urticaria or mild skin reactions | Full-dose challenge |
| Mild/moderate urticaria or other skin reactions Negative skin tests | Graded challenge (1/100 TD or 1/1000 TD when risk is high, e.g. severe asthma) 1/10 TD 2/10 TD 7/10 TD 1 h observation after each dose |
| Positive skin tests Anaphylaxis | Desensitization |
TD, therapeutic dose
