Fig. 6.

Schematic presentation of SGJ preventing the disorders of lysosomal acidification via v-ATPase in senescent BMSCs. a In the process of cell aging, the lysosomal activity is decreasing and the concentration of H⁺ in lysosome is reducing. SGJ can bind to v-ATPase, promote the inflow of H⁺, and inhibit the decrease of the concentration of H⁺ in senescent lysosomes