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. 2018 Dec 7;11:135. doi: 10.1186/s13045-018-0680-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — MSCs-exo regulated the differentiation of T cells from patients with active cGVHD. a, b PBMCs were isolated from patients with active cGVHD, stimulated by T-activator CD3/CD28, and treated with PBS, Fib-exo, or MSCs-exo for 5 days. Consistently, there was a clear reduction of Th17 cells (a) in MSCs-exo-treated cells, whereas the percentage of Treg cells was increased (b). Data are expressed as the mean ± SEM. **P < .01 and ***P < .001; ns not significant