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. 2018 Dec 7;20:273. doi: 10.1186/s13075-018-1768-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Plasma levels of microparticles (MPs) in patients with rheumatoid arthritis (RA) at time zero (baseline (T0)) and after 4 months of treatment (T4) and in healthy controls (HC) and surface expression of TNFα. a Relative distribution of total MPs (TMPs), platelet MPs (PMPs), leukocyte MPs (LMPs) and endothelial MPs (EMPs) in 20 patients with rheumatoid arthritis (RA) and 20 healthy controls (HC). b, c Relative distribution of TMPs, PMPs, LMPs, EMPs (a) and EMPs annexin-V (AV)+ (c) in patients with RA at time zero (baseline (T0) and 4 months after treatment (T4). d Relative distribution of the percentage of the expression of TNFα on the surface of MPs from patients with RA and HC. e Relative distribution of TNFα expression on MPs from patients with RA at T0 and T4. Each data point represents a single subject; horizontal lines show the median. Groups were compared using Student’s t test; *p < 0.05