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. 2018 Oct 20;37:344–355. doi: 10.1016/j.ebiom.2018.10.019

Fig. 3.

Fig. 3

Sutent treatment enhances energy expenditure and improves metabolism in mice under HFD. (a) Body weights of mice treated with sutent or vehicle. (n = 8 for each treatment). (b) Food intake per mouse treated with sutent or vehicle measured over 16 week normalized by body weight. (n = 8 for each treatment). (c) Body lean and fat composition of mice determined by NMR after 14-week treatment with sutent or vehicle. (n = 8 for each treatment). (d) Serum total triglyceride (TG) and total cholesterol (TC) content of mice measured after 15-week treatment with sutent or vehicle. (n = 8 for each treatment). (e) Glucose tolerance test (GTT) performed in mice after 13-week treatment with sutent or vehicle. (n = 8 for each treatment). (f) Insulin tolerance test (ITT) performed in mice after 14-week treatment with sutent or vehicle. (n = 8 for each treatment). (g) Oxygen consumption and CO2 content measurement of mice in metabolic cages after 15-week treatment with sutent or vehicle. (n = 8 for each treatment). Results are means with SD. * P < 0.05, **P < 0.01 (unpaired, two-tailed Student's t-test).