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. 2018 Oct 20;37:344–355. doi: 10.1016/j.ebiom.2018.10.019

Fig. 4.

Fig. 4

Sutent treatment decreases lipid accumulation in adipose and liver tissues and increases UCP1 expression in brown adipose tissue. (a) Weights of different mouse adipose tissues after 16-week treatment with sutent or vehicle under HFD. (n = 8 for each treatment). (b) Representative HE staing images of eWAT, iWAT, and BAT. Scale bar = 100 μm. (c) Representative HE staing (upper) and oli-red staining (lower) images of the liver tissue. Scale bar = 100 μm. (d) Measurement of liver TG and TC content. (n = 8 for each treatment). (e) Measurement of serum AST and ALT levels. (n = 8 for each treatment). (f) The mRNA expression analysis of the Ucp1 gene in mouse brown adipose tissues. (n = 5 for each treatment). (g) Western blot analysis of UCP1 protein expression level in mouse brown adipose tissues. (h) Representative images of immunohistochemistry stainining of UCP1 in BAT. Scale bar = 50 μm. Results are means with SD. *P < 0.05, **P < 0.01 (unpaired, two-tailed Student's t-test).