Fig. 5.

Sutent activates STAT3 signaling pathway and thermogenesis genes in brown adipose tissue. (a) The overview of genes upregulated and downregulated in different tissues after sutent treatment using a cutoff of FDR <0.05. Dark red, upregulated genes; dark blue, downregulated genes. (b) Gene Ontology and pathway analysis of upregulated genes in BAT after sutent treatment identified by RNA-seq. (KP, KEGG Pathway; BP, Biological Process; CC, Cellular Component). (c) Heatmap depicting up- or down- regulated genes identified in Gene Ontology analysis. (d) Western blot analysis of indicated proteins in mouse brown adipose tissues. (e) The schematic diagram of the strategy and discoveries in this study.