Table 1.
In vivo cardiac function of WT and MAP4 KI mice at different ages
| 10-14w (n = 10/10) |
30-34w (n = 11/11) |
70-74w (n = 12/12) |
||||
|---|---|---|---|---|---|---|
| WT | MAP4 KI | WT | MAP4 KI | WT | MAP4 KI | |
| IVSs (mm) | 1.09 ± 0.05 | 1.09 ± 0.05 | 1.16 ± 0.07 | 1.37 ± 0.07* | 1.27 ± 0.06 | 1.57 ± 0.06† |
| IVSd (mm) | 0.84 ± 0.02 | 0.88 ± 0.04 | 0.84 ± 0.02 | 0.96 ± 0.03† | 0.93 ± 0.03 | 1.08 ± 0.02‡ |
| LVPWs (mm) | 1.21 ± 0.07 | 1.26 ± 0.05 | 1.24 ± 0.06 | 1.44 ± 0.07* | 1.34 ± 0.03 | 1.64 ± 0.05‡ |
| LVPWd (mm) | 0.79 ± 0.02 | 0.83 ± 0.05 | 0.79 ± 0.03 | 1.01 ± 0.04‡ | 0.91 ± 0.02 | 1.10 ± 0.03‡ |
| LVIDs (mm) | 1.40 ± 0.09 | 1.49 ± 0.09 | 1.57 ± 0.11 | 1.61 ± 0.08 | 1.61 ± 0.10 | 1.98 ± 0.10† |
| LVIDd (mm) | 3.10 ± 0.10 | 3.02 ± 0.10 | 3.15 ± 0.12 | 3.29 ± 0.09 | 3.35 ± 0.06 | 3.56 ± 0.05 |
| EF (%) | 90.75 ± 1.14 | 90.53 ± 1.00 | 88.69 ± 0.88 | 87.58 ± 1.32 | 86.36 ± 1.42 | 78.26 ± 0.83‡ |
| FS (%) | 55.26 ± 2.01 | 54.60 ± 1.44 | 51.81 ± 1.14 | 50.88 ± 1.84 | 51.47 ± 1.94 | 42.28 ± 1.05‡ |
| Vcf (cir/s) | 8.13 ± 0.41 | 7.16 ± 0.51 | 7.19 ± 0.50 | 6.84 ± 0.38 | 7.16 ± 0.44 | 5.94 ± 0.25* |
| E velocity (m/s) | 0.63 ± 0.03 | 0.67 ± 0.03 | 0.67 ± 0.03 | 0.59 ± 0.03* | 0.64 ± 0.02 | 0.53 ± 0.03† |
| A velocity (m/s) | 0.51 ± 0.03 | 0.56 ± 0.03 | 0.56 ± 0.02 | 0.50 ± 0.02 | 0.53 ± 0.02 | 0.52 ± 0.01 |
| EDT (ms) | 7.27 ± 0.60 | 8.63 ± 0.93 | 7.59 ± 0.44 | 10.01 ± 0.56† | 9.06 ± 0.41 | 12.20 ± 0.70‡ |
| E/A | 1.24 ± 0.03 | 1.21 ± 0.02 | 1.21 ± 0.02 | 1.18 ± 0.02 | 1.22 ± 0.03 | 1.04 ± 0.06 |
| Esa/Asa | 1.34 ± 0.04 | 1.29 ± 0.06 | 1.33 ± 0.06 | 1.07 ± 0.05* | 1.22 ± 0.03 | 0.71 ± 0.02‡ |
| IVRT (ms) | 14.77 ± 1.72 | 15.45 ± 1.29 | 15.91 ± 1.24 | 19.09 ± 1.53 | 21.42 ± 1.24 | 28.12 ± 3.65 |
| IVCT (ms) | 16.70 ± 2.41 | 15.35 ± 1.58 | 14.39 ± 1.42 | 13.24 ± 1.08 | 17.72 ± 1.67 | 16.33 ± 1.85 |
| Tei index | 0.43 ± 0.06 | 0.39 ± 0.04 | 0.43 ± 0.04 | 0.44 ± 0.04 | 0.55 ± 0.04 | 0.62 ± 0.06 |
| ET (ms) | 75.13 ± 2.34 | 78.64 ± 1.92 | 72.22 ± 2.90 | 75.04 ± 1.66 | 71.61 ± 2.34 | 73.77 ± 1.92 |
| LVMM (mg) | 64.96 ± 3.45 | 67.23 ± 4.29 | 67.68 ± 5.23 | 93.81 ± 6.00‡ | 86.79 ± 2.93 | 121.90 ± 3.58‡ |
A velocity, Mitral A velocity; EF, ejection fraction; E velocity, Mitral E velocity; EDT, deceleration time of mitral inflow E; E/A, mitral E velocity relative to mitral A velocity; Esa/Asa, peak E wave of early diastolic at septal annulus relative to peak A wave of late diastolic septal annulus; ET, ejection time; FS, fractional shortening; IVSs, interventricular septal diameter at systole; IVSd, interventricular septal diameter at diastole; IVRT, intraventricular relaxation time; IVCT, intraventricular contraction time; LVPWs, LV posterior wall thickness at systole; LVPWd, LV posterior wall thickness at diastole; LVIDs, LV internal diameter at systole; LVIDd, LV internal diameter at diastole; LVMM, LV muscle mass; Vcf, velocity of circumferential fiber shortening. Data were shown as mean ± SEM (*P < 0.05, †P < 0.01, ‡P < 0.001 vs. the corresponding WT group). P values were derived from one-way ANOVA with Bonferroni's post-test.