Table 2.
Adjusted means (95% confidence intervals) of PROMIS T-scores by CDAI category1
| PROMIS Measures2 | Low CDAI ≤ 10 N = 23 |
Moderate CDAI 10–22 N = 51 |
High CDAI >22 N = 82 |
|---|---|---|---|
| Physical Global Health (95% CI)*** | 45.3 (44.4, 46.1) | 42.6 (41.9, 43.3) | 38.8 (38.3, 39.3) |
| Mental Global Health (95% CI)** | 51.2 (50.6, 51.8) | 49.3 (48.7, 49.9) | 46.1 (45.6, 46.5) |
| Pain Intensity 3a (95% CI)*** | 48.5 (47.8, 49.2) | 50.7 (50.2, 51.2) | 52.9 (52.5, 53.3) |
| Pain Interference (95% CI)** | 57.2 (56.5, 57.9) | 59.6 (59.0, 60.1) | 62.2 (61.8, 62.6) |
| Pain Behavior (95% CI)* | 57.7 (56.9, 58.5) | 58.7 (58.1, 59.3) | 59.8 (59.3, 60.2) |
| Sleep Disturbance (95% CI)*** | 48.9 (48.2, 49.7) | 52.6 (51.9, 53.2) | 56.8 (56.4, 57.2) |
| Sleep-Related Impairment (95% CI)** | 50.0 (48.9, 51.0) | 53.1 (52.3, 53.9) | 57.8 (57.2, 58.4) |
| Fatigue (95% CI)** | 52.9 (52.1, 53.7) | 55.0 (54.4, 55.6) | 58.4 (57.9, 58.9) |
| Anxiety (SD)** | 50.5 (49.2, 51.8) | 52.4 (51.6, 53.2) | 55.3 (54.7, 56.0) |
| Depression (SD)* | 47.7 (46.5, 48.8) | 49.2 (48.5, 49.8) | 52.1 (51.5, 52.7) |
Multivariable models adjusted for study site, gender, race, age, seropositivity, and RA disease duration to predict means by CDAI category and to determine trend across categories.
Differences between groups were all statistically significant at P < 0.001.
indicates P ≤ 0.05;
indicates P ≤ 0.01;
indicates P ≤ 0.001
Global Health and Pain Intensity 3a scores were collected using short forms. All other instruments were collected using computerized adaptive tests. Lower Global Health scores indicate worse global health. For all other measures, high scores indicate worse symptoms. All PROMIS scores range from about 20–80 and are standardized to a general population mean (SD) of 50 (10).