Figure 1.

Long-term decline in physical function score* associated with developing venous thromboembolism (VTE), separated according to the follow-up period in which the VTE occurred.

* Least square mean physical function scores are presented, after adjusting age (continuous), aspirin use, body mass index (<25 kg/m², 25 – <30 kg/m², ≥30 kg/m²), cancer (excluding non-melanoma skin cancer), coronary heart disease (history of myocardial infarction or angina), diabetes, hypertension, non-aspirin nonsteroidal anti-inflammatory drug use, physical activity (measured as average metabolic equivalent of tasks/week), post-menopausal status (including the use of oral contraceptives or post-menopausal hormone replacement), rheumatologic disease (rheumatoid arthritis or systemic lupus erythematosus) and smoking status (never, past, current). Covariates were updated at the beginning of each 4-year time period and we stopped updating covariates after VTE diagnosis. Participants were not censored after VTE. Physical function determined by score on Medical Outcomes Short Form-36 Physical Function Scale; scores can range from 0–100, with higher scores indicating better function. Dotted line indicates time period in which VTE occurred.