Table 1.
iPSC line abbreviation | USI | Patient age at diagnosis | Cell source | Karyotype | JMML-associated mutation |
---|---|---|---|---|---|
Control | CHOP-WT618 | adult | BM | 46,XY | none |
PTPN11 | CHOP-JMML219218 CHOP-JMML2193 |
3.67 years | PB BM |
46,XY | PTPN11 E76K/wt |
CBL | CHOP-JMML185422 | 7 months | BM | 46,XX | CBL Y371H/Y371H |
BM = bone marrow, PB = peripheral blood, USI = unique specimen identifier, wt = wild-type