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. Author manuscript; available in PMC: 2019 Dec 8.
Published in final edited form as: J Thromb Haemost. 2018 Jun 8:10.1111/jth.14197. doi: 10.1111/jth.14197

Fig. 4. GPVI-mediated downstream signaling events are inhibited in TC21-null platelets.

Fig. 4

Washed platelets isolated from TC21-null (TC21 KO) and WT mice were stimulated for the indicated times with CRP (A) at the indicated concentrations or (B) AYPGKF (100 μM) or 2MeSADP (25 nM) (60 sec each), lysed, and lysates were immunoblotted with antibodies as shown. US, unstimulated. Phospho-protein/total protein ratios from six independent experiments are shown to the right in panel A for 2.5 μg/ml CRP treatment. Representative blots are shown. *, p < 0.03.