Table 2.
Effect of C. afer on biochemical parameters in streptozotocin-diabetic rats.
|
Biochemical Parameters |
Normal Control |
Diabetic Control |
DHE 250 mg/Kg | DHE 500 mg/Kg | DHE 1000 mg/Kg | Metformin |
|---|---|---|---|---|---|---|
| ALT (UI/L) | 76.92±6.68a | 89.86±27.08b∗ | 76.46±5.13a | 75.54±5.26a | 74.92±4.32a | 74.15±4.68a |
|
AST (UI/L) |
15.86±1.29b | 19.89±2.21c∗ | 15.73±0.91b | 15.43±0.52b | 12.36±2.66a | 12.48±1.73a |
|
ALP (UI/L) |
7.90±1.05b | 15.15±1.23a∗ | 8.82±3.29b | 7.35±1.13b | 10.11±1.59c | 10.84±2.19c |
|
LDH (UI/L) |
160±20.19b | 212±31.14c∗ | 199±16.00b | 191±69.41b | 218±29.76a | 175±48.73b |
| CRE (mg/dL) | 1.01±0.14c | 1.64±0.04a | 1.23±0.15b | 0.92±0.16c | 0.83±0.04d | 0.80 ±0.12d |
| UREA (mg/dL) | 47.59±3.02b | 70.97±17.92c∗ | 64.85±9.98b.c | 43.75±13.87b | 47.94±6.12b | 25.85±2.98a∗ |
| BIL (mg/dL) | 2.33±0.61a | 2.65±0.14c | 1.98±0.26c | 2.57±0.08b | 2.68±0.13b | 2.77±0.11a |
| Total Protein (mg/dL) | 67.56±6.95b | 70.55±4.54c | 67.40±2.69b | 63.75±3.17b | 67.33±2.19b | 53.41±13.67a |
AST (Aspartate transaminase); ALT (Alanine transaminase); ALP (Alkaline phosphatase); LDH (lactate dehydrogenase); CRE (Creatinine); BIL (bilirubin total). The data represents the Mean ± SD for each group of rats. n = 6 (number of animals per group); ∗p<0.05 = significant difference.