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A proposed mechanism of action for the protective effect of PDTC in DON-mediated mitochondrial dysfunction and apoptosis. DON indirectly activates the NF-κB signal pathway via the classical route of IκB/NF-κB p65 signaling. PDTC inhibits the translocation of NF-κB p65 and the transcription of iNOS, and thereby protects cells from mitochondrial dysfunction and cell apoptosis.
