Table 2.
Accuracy of ELISAs for detection of leprosy using different M. leprae antigens. Summary points of the HSROC curve accuracy for each M. leprae antigen used in the ELISAs for each population studied.
| ELISA antigen/Op. class∗ | Sensitivity % | 95% CI | Specificity % | 95% CI | LR+ | 95% CI | LR− | 95% CI | DOR | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|
| PGL-I | ||||||||||
| MB | 78 | 60–90 | 99 | 91–99 | 90 | 8–1023 | 0.22 | 0.11–0.44 | 408 | 23–7041 |
| PB | 34 | 11–67 | 97 | 89–99 | 16 | 2–121 | 0.67 | 0.42–1 | 22 | 2.4–247 |
| ND-O-BSA | ||||||||||
| MB | 94 | 78–98 | 99 | 97–99 | 129 | 42–390 | 0.05 | 0.01–0.23 | 2293 | 279–18844 |
| PB | 56 | 27–81 | 99 | 98–99 | 76 | 21–274 | 0.43 | 0.21–0.87 | 174 | 39–1013 |
| LID-1 | ||||||||||
| MB | 79 | 66–88 | 97 | 91–99 | 26 | 8–90 | 0.2 | 0.11–0.37 | 127 | 22–721 |
| PB | 20 | 7–46 | 97 | 92–99 | 8 | 3.0–24 | 0.81 | 0.64–1 | 9.8 | 2.8–33 |
∗Op. class = operational classification; 95% CI = 95% confidence interval; LR− = negative likelihood; LR+ = positive likelihood ratio; DOR = diagnostic odds ratio.