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. 2018 Dec 8;15:338. doi: 10.1186/s12974-018-1377-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Knocking down of βCaMKII in CA1 rescued depression-like behaviors of depressed rats. a Schematics of AAV vectors engineered to overexpress a control construct or RNAi form of βCaMKII. H1, human H1 promoter. b Experimental paradigm for behavioral testing of rats infected by virus. c Illustration of viral infusion of βCaMKII RNAi construct into the CA1. Scale bar is 200 μm. d, e Behavioral effects after expressing AAV-βCaMKII RNAi construct within the CA1 of depressed rats. N = 18 per group. Data are presented as the means ± SEM. *P < 0.05, **P < 0.01 CUMS+AAV-βi vs CUMS; ^#P < 0.05, ^##P < 0.01 CUMS+AAV-βi vs CUMS+AAV-control (AAV-βi, AAV-βCaMKII RNAi)