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Inhibition of Egr-1 attenuated myocardial injury following CME. Egr-1 downregulation rapidly reduced the serum cTnI level after CME modeling. The results are presented as the means ± SD from at least three independent experiments. aP < 0.05 compared with the Sham group; bP < 0.05 compared with the CME group; cP < 0.05 compared with the CME+shRNA group.
