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Activation of the Egr-1/Bim/Beclin-1 pathway participated in CME-induced myocardial injury. The expression of (A) the Egr-1, (B) Bim, and (C) Beclin-1 mRNAs in the myocardium of rat detected by RT-qPCR. The results are presented as the means ± SD from at least three independent experiments. aP < 0.05 compared with the Sham group; bP < 0.05 compared with the CME group; cP < 0.05 compared with the CME+shRNA group.
