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. 2018 Nov 12;10(11):3229–3248. doi: 10.18632/aging.101627

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Copyright © 2018 Salissou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TG decreased the phosphorylation level of tau by modulated tau related phosphatase and kinases. (A-D) Western blotting and quantitative analysis of total glucose synthase kinase 3β (GSK3β), phosphorylated GSK3β at Ser9 (GSK3β-pS9) and total protein phosphatase 2A (PP2A) (n = 6). No significant difference in the total level of either GSK3β or PP2A among all groups, but the GSK3β-pS9 was significantly high in HHcy and was reduced following TG supplementation. GSK3β (E) and PP2A (F) activity tests (n = 3) revealed an increased GSK3β and a decreased PP2A activity after Hcy which were reversed by both low and high TG treatments. The data were expressed as mean ± SEM. # P < 0.05, ## P < 0.01, #### P <0.0001 versus control; * P < 0.05, ** P < 0.01, **** P < 0.0001 versus HHcy.