Table 2. Characteristic of studies with liver transplantation and translational medical research.
| Reference year | Type of article | Sample | N | Intervention | Outcomes |
|---|---|---|---|---|---|
| Ischemia-reperfusion (IRI) | |||||
| Qin 2016 (4) | Original | Animal | – | Short-term starvation | Attenuates liver IRI via the Sirt1-autophagy pathway |
| Zhuang 2016 (5) | Original | Animal | – | Dichloroacetate diisopropylamine | Recovery of donor liver function after transplantation |
| Emadali 2006 (6) | Original | Human | – | Proteomic analysis of IRI | Regulation of IRI-induced cytoskeleton remodeling and led to the identification of IQGAP1 as a regulator of bile canaliculi |
| Jassem 2009 (7) | Original | Human | 19/16 | IPC (× IRI) | Reduction in the expression of immune response genes and promotion of those involved in protection and repair |
| Kristo 2011 (8) | Original | Human, RCT | 13/13 | TAC (× Placebo) | Did not enhance early graft function (AST, ALT) in the donor graft |
| Raza 2010 (9) | Original | Human, RCT | – | IPC (× standard organ recovery) | Increases expression of transcripts which are likely to increase antioxidant defenses. |
| Cursio 2010 (10) | Leading | – | – | Caspase inhibitors | Cold ischaemia/normothermic reperfusion injury |
| Selzner 2012 (11) | Review | – | – | – | Mechanisms of pre-, post-, and remote conditioning of solid organs |
| Zhai 2013 (12) | Review | – | – | – | Innate-adaptive immune crosstalk and cell activation cascades |
| Immunosuppression | – | – | – | ||
| Goto 2014 (13) | Abstract | – | – | Anti-nuclear histone H1antibody | Histone H1 was upregulated during liver fibrosis |
| Nakano 2010 (14) | Abstract (p-194) | Animal (rat) | – | Hepatic mast cells, OLT | Stem cell factor is an important factor for proliferation and maturation of mast cells |
| Parikh 2014 (15) | Editorial | – | – | – | – |
| Egawa 2012 (16) | Original | Human | 158 | TAC, LDLT and non-inflammatory central sinusoidal fibrosis (NICSF) | NICSF might be an indicator of inadequate immunosuppression in pediatric patients under TAC withdrawal |
| Hsu 2007 (17) | Original | Human | 15 | Cyclosporin, biliary atresia | Detection of several proteins associated with a drug-free OLT patient |
| Fukudo 2008 (18) | Original | Human | 60 | TAC,living-donor liver transplantation (LDLT) | CYP3A5*1 genotype as well as the MDR1 mRNA level in enterocytes contributes to interindividual variation in the CL/F of TAC in adult recipients early after living-donor liver transplantation |
| Crettol 2008 (19) | Original | Human | 64 | Cyclosporine, renal, liver or lung transplant | ABCB1 polymorphisms (1199A and 3435T carriers) influence cyclosporine intracellular concentration |
| Smith 2008 (20) | Original | Human | 163 | Calcineurin inhibitors (CNIs), LT patients receiving CNIs for at least 3 years | CYP2C8*3 is associated with a higher risk of developing renal toxicity in patients treated chronically with CNIs |
| Chen 2013 (21) | Original | Human | 96 | TAC, LT | Combined SNPs of donor CYPA5 rs776746, IL6 rs1800796, and recipient CYP3A5 rs776746 have a greater effect on TAC metabolism than CYP3A5 rs776746 |
| Levitsky 2013 (22) | Original | Human | 20 | TAC to Sirolimus, LT | CNI to SRL conversion after LT could take advantage of the regulatory properties of SRL |
| Chen 2014 (23) | Original | Human | 96 | TAC, LT | Hb, donor CYP3A5, NR1I3 gene polymorphisms, and recipient CYP3A5 gene SNPs were associated with TAC pharmacokinetics. |
| Kurian 2015 (24) | Original | Human | 40/36 | EAD/non-EAD | Relevant pathways (PPARa and NF-kB) and targets (CXCL1, IL1, TRAF6, TIPARP, and TNFRSF1B) are associated with the phenotype of EAD |
| Béland 2014 (25) | Original | Human | – | Cyclosporine or TAC, OLT pediatric | High prevalence of infection and a high Torque Teno virus load among OLT recipients; Viral load was influenced by immunosuppressive regimen |
| Elens 2007 (26) | Original, prospective | Human | 150 | TAC, Liver donors | CYP3A5 SNPs in liver tissue is significantly associated with TAC dose requirement; SLCO1B1 seem to influence early trough blood concentrations, SNPs in ABCB1 seem to influence the TAC hepatic levels and the graft outcome |
| Tapirdamaz 2014 (27) | Original, retrospective | Human | 125 | TAC, LT | CYP3A5 and ABCB1 genes were not significant risk factor for the development of CKD after LT |
| Li 2015 (28) | Review | – | – | – | Roles of CXCL4 and CXCL4L1 in the pathogenesis of chronic liver allograft dysfunction |
| Small-for-size syndrome | |||||
| Hsu 2015 (29) | Original | Animal (rat) | – | Granulocyte colony-stimulating factor (G-CSF), dipeptidyl peptidase IV (DPP-IV) inhibitor | Combined treatment may synergistically induce migration and differentiation of recipient-derived stem cells into the hepatic progenitor cells |
| Chen 2011 (30) | Original | Animal (rat) | – | miRNA expression profile, partial hepatectomy (PH) LT | Down-regulated miRNAs play a pivotal role in promoting the growth of small size grafts and the remaining liver after PH |
| Iguchi 2014 (31) | Original | Animal (pig) | – | Olprinone, hepatectomy model | OLP may have the therapeutic potential to overcome PHLF and SFSS |
| Acute cellular rejection | |||||
| Nakano 2012 (32) | Original | Animal (rat) | – | Immunological and regenerative aspects of hepatic mast cells in liver allograft rejection and tolerance, OLT | Early induction of c-Kit, Foxp3+ Tregs, and cd T cells may be indispensable for overcoming acute rejection and that Foxp3+ Tregs, CD T cell |
| Wei 2015 (33) | Original | Animal (rat) | – | Biomarkers of the chronic rejection, OLT | CLU, Lcn2 and Krt19 were identified and quantified as early and reliable biomarkers |
| Xu 2014 (34) | Original | Animal (rat) | – | Biomarkers of immune response, OLT | HPX serves as a negative predictor for AR of liver allograft |
| Cheng 2010 (35) | Original | Animal (rat) | – | Global protein expression changes in liver allograft during AR | Altered protein expressions act coordinately in hepatocyte dysfunction by depressed energy, enhanced oxidative stress-induced molecular damage and restrained biotransformation |
| Wu 2009 (36) | Original | Animal (rat) | – | Variation of serum metabolites, OLT | Changes in metabonomic profiles reflected in the graft injury are correlated with histological changes instead of classical liver function |
| Gehrau 2016 (37) | Abstract | Human | 22 | DNA methylation patterns, post-LT | CpGs methylation identified apoptosis activation signaling, ubiquitin protein degradation, and cell cycle regulation. CpGs hypomethylation increases in liver cell death and G1/S cell cycle check-point |
| Taubert 2012 (38) | Original, prospective | Human | 151 | Intrahepatic T cell infiltration pattern in correlation to the severity of ACR | Active role of regulatory T cells (Tregs) in controlling rejection |
| Joshi 2013 (39) | Original | Human | 29 | Intragraft miRNA expression profiles, recurrent HCV from ACR post-LT | miRNA-19a and miRNA-20a could represent potential serum biomarkers for fibrosis progression |
| Uesugi 2014 (40) | Original | Human | 412 | TAC, ACR post-LT | Graft liver CYP3A5*1 genotype might increase the risk for ACR after living-donor LT |
| Bonaccorsi-Riani 2016 (41) | Original, prospective | Human | 55 | Molecular Characterization, ACR post-LT | Potential utility of transcriptional markers in peripheral blood as a predictor for rejection |
| Ningappa 2016 (42) | Original | Human (pediatric) | 62/60 | Rabbit antihuman thymocyte globulin and steroid-free TAC, non-rejector/rejector | Association between rs9296068 HLA-DOA gene and LT rejection |
| Miscellaneous | |||||
| Yagi 2013 (43) | Original | Animal (rat) | – | Venous systemic oxygen persufflation (VSOP) with nitric oxide (NO) gas, partial liver preservation and LT | Novel and safe preservation method that improve liver regeneration after transplantation |
| Zhou 2014 (44) | Original | Animal (rat) | – | Arterialized OLT | Done quickly with a high patency rate |
| Dong 2016 (45) | Original | Animal (pig) | – | Development of an organ culture system | Liver function can be maintained in ex situ organ culture without the use of erythrocytes |
| Orlando 2011 (46) | Review | – | – | – | Recent advances in the engineering of several key tissues and organs |
| Hashmi 2015 (47) | Review | – | – | – | Genomics of liver transplant injury and regeneration |
Number and percentages. EAD, Early allograft dysfunction; IPC, Ischemic preconditioning; IRI, ischemia/reperfusion injury; LT, Liver Transplantation; TAC, Tacrolimus; TMR, Translational Medical Research.