Table 2. Cause-specific survival in cholangiocarcinoma by patient demographic characteristics.

Characteristic	N	Median survival (months)	Univariate				Multivariate
			HR (95% CI)	P value	Overall P value		HR (95% CI)	P value	Overall P value
Sex					0.04				0.004
Female	2,820	5	1.00 (ref)	–			1.00 (ref)	–
Male	2,796	4	1.07 (1.00–1.13)	0.04			1.10 (1.03–1.16)	0.004
Age cohort, years					<0.001				<0.001
<50	618	7	1.00 (ref)	–			1.00 (ref)	–
50–70	2,780	5	1.14 (1.04–1.26)	0.008			1.17 (1.06–1.29)	0.003
>70	2,218	4	1.39 (1.25–1.54)	<0.001			1.44 (1.30–1.59)	<0.001
Year					<0.001				<0.001
1990–2000	891	3	1.00 (ref)				1.00 (ref)
2001–2009	2,585	4	0.91 (0.84–0.99)	0.03			0.90 (0.82–0.97)	0.01
2010–2013	2,140	6	0.79 (0.72–0.86)	<0.001			0.78 (0.71–0.85)	<0.001
Race/ethnicity					0.02				<0.001
Non-Hispanic White	3,577	5	1.00 (ref)	–			1.00 (ref)	–
Non-Hispanic Black	485	3	1.15 (1.04–1.29)	0.01			1.21 (1.09–1.35)	<0.001
Non-Hispanic Asian or Pacific Islander	658	5	0.96 (0.87–1.06)	0.41			0.98 (0.89–1.08)	0.65
Non-Hispanic American Indian/Alaska Native	48	5	1.02 (0.73–1.42)	0.91			1.06 (0.76–1.48)	0.72
Hispanic (all races)	848	4	1.09 (1.00–1.19)	0.05			1.15 (1.05–1.25)	0.002