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. 2018 Dec 3;12:865. doi: 10.3389/fnins.2018.00865

FIGURE 2.

FIGURE 2

Rapamycin enhanced mitophagy via promoting p62, Parkin translocation to the mitochondria. (A–C) Representative western blots and quantitative graphs demonstrate the expression of p62 in the whole homogenates, in the cytosolic fractions and in the mitochondrial fractions at 24 h after SCIRI. Data were shown as mean ± SD, n = 6. ∗p < 0.05, ∗∗p < 0.01 vs; Sham, #p < 0.05, ##p < 0.01. (D-F) Representative western blots and quantitative graphs demonstrate the expression of Parkin in the whole homogenates, in the cytosolic fractions and in the mitochondrial fractions at 24 h after SCIRI. Cox- IV is as inner control for mitochondria protein, β-actin is as inner control for tissue homogenate protein. Data were shown as mean ± SD, n = 6. ∗p < 0.05, ∗∗p < 0.01 vs. Sham; #p < 0.05, ##p < 0.01.