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Schematic presentation of GPR97 signaling and function in human granulocytes. GPR97 signaling provides basal Gαs/cAMP-mediated signal transduction, which has been shown to inhibit NF-κB transcriptional activity (52). Removal or ligation of the NTF of GPR97 activates Gαi/o-induced reduction of cAMP levels, in combination with an increase in downstream effectors of Gβγ, such as NF-κB and MAPKs (ERK and p38), which triggers neutrophilic antimicrobial functions.
