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. 2018 Dec 3;11:449. doi: 10.3389/fnmol.2018.00449

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Copyright © 2018 Naranjo, González, Lopez-Hurtado, Dopazo, Mellström and Naranjo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of endogenous DREAM levels on PS2 endoproteolysis and PS2 gene expression. (A) Quantified Western blots with anti-PS2 antibody of hippocampal (Hpp) and cortical (Cx) extracts from wild-type (WT), DREAM deficient knockout (KO) and transgenic mice overexpressing dominant active DREAM (daDREAM). (B) Quantitative PCR (qPCR) analysis of PS2 mRNA levels in the hippocampus and the cerebral cortex from the same three genotypes as in (A). Ordinary one-way ANOVA with Holm-Sidak’s multiple comparison test (n = 11, for each genotype) *P < 0.05, **P < 0.01, ***P < 0.001.