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. 2018 Dec 3;12:88. doi: 10.3389/fninf.2018.00088

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Copyright © 2018 Geminiani, Casellato, Locatelli, Prestori, Pedrocchi and D'Angelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Responses to synaptic inputs. Simulation of the neuron model response to synaptic inputs on two synaptic receptor mechanism (R_exc and R_inh). The synaptic models are conductance-based, with an alpha-shaped conductance change. As shown in (A), the excitatory spike train (bottom panel–red) increases irregularity in neuron firing (top panel), while the inhibitory input burst (bottom panel–blue) produces the rebound burst. Synaptic conductances are modified according to an alpha function, with delay 0.1 ms and maximum change depending on the weight of the synapse (middle panel). A zoom on the conductance change is shown in (B).