Table 5.

Correspondence between subcellular mechanisms that generated specific electrophysiological properties and how they were simplified in E-GLIF model elements.

Ionic channel mechanisms	Electrophysiological property	E-GLIF mechanisms
INa−t ↑ / IK−V ↓ balance	Action potential	Digital
Ih ↑INa−p ↑ / IK−slow ↓ balanceICa−HVA ↑/ IK−AHP ↓ balance	Autorhythmicity	Ie ↑/ Iadap↓ balance
INa−r ↑ and IK−A ↓	Depolarization-induced burst	Idep↑
ICa−HVA ↑/ IK−AHP ↓ balanceIK−slow ↓	Spike-frequency adaptation	Iadap ↓
ICa−HVA ↑/ IK−AHP ↓ balance	Phase-reset	Iadap↓
Ih ↑ICa−LVA ↑	Post-inhibitory rebound burst	Iadap ↑ and Idep ↑
IK−slow ↓ and INa−p ↑	Subthreshold oscillations	Vm–Iadap coupling
IK−slow ↓ and INa−p ↑	Resonance	Vm–Iadap coupling

The arrow indicate depolarizing (↑) and hyperpolarizing (↓) actions of the membrane currents in the real cell and models. I_Na−t: transient sodium current; I_K−V: delayed rectifier potassium current; I_h: hyperpolarization-activated current; I_Na−p: persistent sodium current; I_K−slow: slow M-like potassium current; I_Ca−HVA: high voltage-activated calcium current; I_K−AHP: SK-type calcium-dependent potassium current; I_Na−r: resurgent sodium current; I_K−A: A-type potassium current; definitions and properties of the ionic currents are given in (Forti et al., 2006; Solinas et al., 2007a,b).