Table 4.
Drug exposure (days’ supply) and classification of patients as adherent (PDC ≥ 80%) or non-adherent (PDC < 80%), according to different approaches to calculate PDC.
| PD Cohort |
D1 Cohort |
D2 Cohort |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDC < 80 | PDC ≥ 80 | Total | PDC < 80 | PDC ≥ 80 | Total | PDC < 80 | PDC ≥ 80 | Total | ||
| Days’ supply | <80% | 2,218 | 7,719 | 9,572 | 40 | 7,236 | 21 | |||
| (5.8%) | (20.3%) | (25.3%) | (0.1%) | (20.4%) | (0.1%) | |||||
| ≥80% | 0 | 28,089 | 0 | 28,202 | 0 | 28,200 | ||||
| (0.0%) | (73.9%) | (0.0%) | (74.6%) | (0.0%) | (79.5%) | |||||
| Total | 2,218 (5.8%) | 35,808 (94.2%) | 38,026 | 9,572 (25.3%) | 28,242 (74.7%) | 37,814 | 7,236 (20.4%) | 28,221 (79.6%) | 35,457 | |
| PD cohort | PDC < 80 | 1,909 | 98 | 1,396 | 89 | |||||
| (5.0%) | (0.3%) | (3.9%) | (0.3%) | |||||||
| PDC ≥ 80 | 7,663 (20.3%) | 28,144 (74.4%) | 5,840 (16.5%) | 28,132 (79.3%) | ||||||
| Total | 9,572 (25.3%) | 28,242 (74.7%) | 37,814 | 7,236 (20.4%) | 28,221 (79.6%) | 35,457 | ||||
| D1 cohort | PDC < 80 | 7,236 (20.4%) | 0 (0.0%) | |||||||
| PDC ≥ 80 | 0 (0.0%) | 28,221 (79.5%) | ||||||||
| Total | 7,236 (20.4%) | 28,221 (79.5%) | 35,457 | |||||||
PDC, proportion of days covered; PDC80, percentage of patients with PDC ≥ 80%; PD, prescription-dispensation cohort; D1, dispensation-only cohort with at least 1 refill; D2, dispensation-only cohort with at least two refills. Shaded cells indicate discrepancies in adherence classification according to different approaches for PDC estimation.