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. 2018 Dec 3;9:1405. doi: 10.3389/fphar.2018.01405

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Copyright © 2018 Pellegrini, Fornai, Colucci, Benvenuti, D’Antongiovanni, Natale, Fulceri, Giorgis, Marini, Gastaldi, Bertinaria, Blandizzi and Antonioli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Hematoxylin and eosin-stained sections of rat colon. Representative microscopic images refer to control rats or animals with colitis induced by DNBS. (B) Microscopic damage score estimated for colon in rats under normal conditions or with DNBS-induced colitis, either alone or after treatment with Ac-YVAD-cmk (YVAD, 3 mg/Kg), anakinra (100 mg/Kg), INF39 (25 mg/kg) or DEX (1 mg/kg). Each column represents the mean ± S.E.M. (n = 10). ^∗P < 0.05, significant difference vs. control group; ^aP < 0.05, significant difference vs. DNBS group.