Table 1.
Synoptic presentation of percent changes of tissue-related inflammatory parameters in DNBS-rats treated with YVAD, anakinra, INF39 or DEX against values estimated in animals with colitis.
Colon length | Macroscopic damage score | Microscopic damage score | MPO | TNF | IL-1β | |
---|---|---|---|---|---|---|
YVAD | + 7.6 | −38.1 | −37.7 | −61.5 | +18.5 | −32.4 |
Anakinra | + 20.1 | −55.1 | −50.9 | −66.7 | + 4.5 | −12.6 |
INF39 | + 22.1 | −62.8 | −67.8 | −83.4 | −50.5 | −65.5 |
DEX | + 18.4 | −71.8 | −73.5 | −90.1 | −57.4 | −76.3 |
DEX, Dexamethasone; DNBS, 2,4-dinitrobenzenesulfonic acid; TNF, tumor necrosis factor; IL-lβ, interleukin-l beta; MPO:myeloperoxidase.