Table 1.
Characteristics of the included studies.
| References | Local | Sample size | Average age# | Type of steroids | Primary disease | Genes | NOS score |
|---|---|---|---|---|---|---|---|
| Zhao et al., 2017 | China | 193 (78/115) | 40 (18–48) | Prednisone | SLE; ALL; RT; LT; NS; RA; AS | GRG | 9 |
| Plesa et al., 2017 | Caucasian | 304 (32/272) | NA | Prednisone | ALL | BCL2L11 | 9 |
| Karol et al., 2015 | Multinational | 2955 (400/2555) | NA | Prednisone; dexamethasone | ALL etc. | GWAS | 7 |
| Wei et al., 2015 | China | 75 (45/30) | 39 ± 10 | Prednisone | SLE; NS; ENT; dermatologic disease | ApoA1; ApoB; ApoE | 8 |
| Zhang et al., 2014 | China | 200 (94/106) | 44.5 (18–82) | Prednisolone | Hematologic; dermatologic; renal; ophthalmopathy; respiratory disease, etc. | ABCB1 | 7 |
| Xue et al., 2014 | China | 322 (105/217) | 39 (18–48) | Prednisone | SLE; ALL; OT | ABCB1 | 9 |
| Cui et al., 2014 | China | 424 (223/201) | 42.27 ± 15.71 | Prednisolone | NA | ApoA5 | 7 |
| Zeng et al., 2014 | China | 206 (108/98) | 40 ± 10 | Prednisone | SLE; NS; RT; Purpura; ENT; dermatologic disease | ApoB | 8 |
| Zhang et al., 2013 | China | 200 (94/106) | 44.5 (18–82) | Prednisolone | Hematologic; dermatologic; renal; ophthalmopathy; respiratory disease, etc. | PAI-1 | 7 |
| Wang et al., 2013 | China | 200 (94/106) | 44.5 (18–82) | Prednisolone | Hematologic; dermatologic; renal; ophthalmopathy; respiratory disease, etc. | PON-1 | 6 |
| Li et al., 2012 | China | 123 (70/53) | 29 (18–73) | Prednisone | NA | ABCB1 | 6 |
| Wei, 2011a | China | 134 (63/71) | 35.17 ± 11.73 | Prednisone | NA | ApoB; CYP1A2 | 8 |
| Wei, 2011b | China | 134 (63/71) | 35.17 ± 11.73 | Prednisone | NA | Factor V; GR; CBP; ApoB; CYP1A2 | 8 |
| Bond et al., 2011 | UK | 110 (43/67) | NA | Dexamethasone | ALL | PAI-1 | 8 |
| He and Li, 2009a | China | 48 (31/17) | 32 (12–59) | NA | Hemoglobinopathies | CYP3A4; ABCB1 | 7 |
| He and Li, 2009b | China | 48 (31/17) | 18–60 | Prednisone | SLE; RA; psoriasis; nephropathy; desmosis, etc. | CYP3A4 | 7 |
| Kuribayashi et al., 2008 | Japan | 157 (34/123) | 35 (9–64) | Methylprednisolone; prednisolone | RT | ABCB1; ApoB; CBP | 9 |
| French et al., 2008 | USA | 361 (51/310) | NA (10–20) | Prednisone; dexamethasone | ALL | ABCB1; PAI-1 et al. 11 Genes## | 7 |
| Wang et al., 2008 | China | 53 (16/37) | 35 (16–78) | Methylprednisolone | RT | TNF-α | 8 |
| Tamura et al., 2007 | Japan | 157 (34/123) | 35 (9–64) | Methylprednisolone; prednisolone | RT | GR; CYP3A4; CBP; NCoA2 | 9 |
| Yang and Xu, 2007 | China | 127 (21/106) | 34 (11–67) | Methylprednisolone; prednisone | SLE | ABCB1 | 9 |
| Hirata et al., 2007a | Japan | 112 (20/92) | NA | Methylprednisolone; prednisone | SLE | ApoA | 7 |
| Hirata et al., 2007b | Japan | 158 (34/124) | 36.1 (9–64) | Methylprednisolone; prednisolone | RT | ApoB | 7 |
| Ekmekci et al., 2006 | Turkey | 57 (19/38) | 34.2 ± 9.3 | NA | RT | Factor V; Prothrombin | 7 |
| Celik et al., 2006 | Turkey | 50 (11/39) | 41 ± 11.79 | Prednisolone | RT | Factor V; Prothrombin; MTHFR | 8 |
| Relling et al., 2004 | USA | 64 (25/39) | 8.6 (2.7–18.8) | Prednisone | ALL | MDR1(ABCB1) et al. 13 Genes### | 8 |
| Asano et al., 2004 | Japan | 137 (31/106) | 36 (9–63) | Methylprednisolone; prednisolone | RT | PAI-1; MTHFR | 8 |
| Asano et al., 2003a | Japan | 80 (26/54) | NA | NA | RT | CYP3A4; CYP2D6; CYP2C19 | 7 |
| Asano et al., 2003b | Japan | 136 (30/106) | 35.5 (9–63) | Methylprednisolone; prednisolone | RT | ABCB1 | 8 |
| Ferrari et al., 2002 | Switzerland | 228 (26/202) | 50 ± 12 | Prednisone | RT | PAI-1 | 8 |
ALL, Acute lymphoblastic leukemia; AS, Ankylosing spondylitis; ENT, Ear, nose, and throat; GWAS, Genome-wide association study; LT, Liver transplant; NA, Not available; NOS, Newcastle-Ottawa Scale; NS, Nephrotic syndrome; OT, Organ transplant; RA, Rheumatic arthritis; RT, Renal transplant; SLE, Systemic lupus erythematosus.
#
: Mean ± Standard deviation; Mean/Median (Minimum-Maximum).
##
: TYMS; VDR; BGLAP; ESR1; LRP5; MTHFR; PAI-1; ABCB1(MDR1); PTH; PTHR; ACP5.
###
: CYP3A4; CYP3A5; TPMT; UGT1A1; TYMS; GSTT1; GSTM1; RFC; MTHFR; GRG(NR3C1); MDR1(ABCB1); VDR; GSTP1.