Table 3.
GO and KEGG annotations of possibly related genes for SONFH in this research.
| Genes | Gene name | Biological process | Molecular function | Cell component | KEGG |
|---|---|---|---|---|---|
| ABCB1# | ATP-binding cassette subfamily B member 1 | lipid localization;regulation of membrane lipid distribution | lipid transporter activity; drug transporter activity | Apical part of cell | ABC transporters; Bile secretion |
| APOB# | Apolipoprotein B | Macromolecular complex remodeling;Lipid localization;Foam cell differentiation;Protein-lipid complex subunit organization;Response to inorganic substance;Regulation of plasma lipoprotein particle levels | Lipid transporter activity; Lipoprotein particle receptor binding | Endoplasmic reticulum lumen;Protein-lipid complex;Cell body;Vesicle lumen | Vitamin digestion and absorption; Fat digestion and absorption |
| BAZ2A | Bromodomain adjacent to zinc finger domain 2A | NA | Ligand-dependent nuclear receptor binding | Transcriptional repressor complex | NA |
| KLF12 | Kruppel-like factor 12 | NA | |||
| GRIN3A | Glutamate ionotropic receptor NMDA type subunit 3A | NA | Glutamate receptor activity; Metal ion transmembrane transporter activity; Passive transmembrane transporter activity | Transporter complex;Cell body | Nicotine addiction; Cocaine addiction; Amphetamine addiction |
| COL22A1 | Collagen type XXII alpha 1 chain | NA | NA | Endoplasmic reticulum lumen;collagen trimer | NA |
| FAT1 | FAT atypical cadherin 1 | NA | NA | NA | NA |
| CABIN1 | Calcineurin-binding protein 1 | NA | Phosphatase regulator activity | Inclusion body | NA |
| AMPD1 | Adenosine monophosphate deaminase 1 | Cellular metabolic compound salvage | Deaminase activity; Myosin binding | NA | NA |
| KCNMA1 | Potassium calcium-activated channel subfamily M alpha 1 | Renal system process;Response to inorganic substance;Excretion | Metal ion transmembrane transporter activity; Passive transmembrane transporter activity | Transporter complex;Apical part of cell | Renin secretion; Insulin secretion; Salivary secretion |
| PCSK5 | Proprotein convertase subtilisin/kexin type 5 | Renal system process | NA | Golgi lumen | NA |
#
The gene results are based on traditional meta-analysis; others are based on Genome Wide Association Study-related meta-analysis.