Table 1.
Demographics AD cohort and controls
| Total |
Training |
Validation |
||||
|---|---|---|---|---|---|---|
| Controls | AD | Controls | AD | Controls | AD | |
| N (%) | 442 (31) | 1004 (69) | 221 (50) | 221 (50) | 221 (22) | 783 (78) |
| Age, years (SD) | 64.4 (6.3) | 67.3 (7.2)* | 64.4 (6.5) | 67.3 (7.0)* | 64.4 (6.0) | 67.2 (7.2)* |
| Females, n (%) | 273 (62) | 490 (49)* | 132 (60) | 110 (50)* | 141 (64) | 380 (49)* |
| Level of education (SD)† | 5.4 (1.3) | 4.8 (1.3)* | 5.4 (1.3) | 4.9 (1.4)* | 5.4 (1.2) | 4.8 (1.3)* |
| MMSE score (SD) | 28 (1.7) | 21 (4.9)* | 28 (1.7) | 20 (5.1)* | 28 (1.7) | 21 (4.9)* |
| APOE ε4 allele carriers, n (%) | 157 (36%) | 598 (60%) | 73 (33%) | 131 (59%)* | 84 (38%) | 467 (60%)* |
| CSF Aβ1-42 (SD), pg/ml | 1055 (259) | 656 (168)* | 1049 (249) | 672 (179)* | 1062 (269) | 651 (165)* |
| CSF Tau (SD), pg/ml | 318 (206) | 706 (406)* | 320 (204) | 686 (408)* | 317 (208) | 711 (406)* |
| CSF Ptau (SD), pg/ml | 51 (24) | 87 (39)* | 51 (25) | 86 (38)* | 51 (23) | 87 (38)* |
Data are mean (SD), unless otherwise specified. Independent T-test, Kruskal-Wallis test, or chi square test was used when applicable. *P < .05: AD differs from SCD.
Abbreviations: SCD, Subjective Cognitive Decline, served as controls; AD, Alzheimer's disease; MMSE, Mini-Mental State Examination; APOE, Apolipoprotein E; Aβ42, amyloid β 1-42; Ptau, tau phosphorylated at threonine 181; SD, standard deviation.
†
According to the Verhage system.